Trump blasted Reiner, who was strongly opposed to Trump’s politics and was  noted supporter of Democratic causes, as having “Trump Derangement Syndrome” in a post on social media Monday.

Trump wrote in a post on Truth Social: “A very sad thing happened last night in Hollywood. Rob Reiner, a tortured and struggling, but once very talented movie director and comedy star, has passed away, together with his wife, Michele, reportedly due to the anger he caused others through his massive, unyielding, and incurable affliction with a mind crippling disease known as TRUMP DERANGEMENT SYNDROME, sometimes referred to as TDS.”

mong Reiner’s remarks opposing Trump and his policies, Reiner said in 2017, “Donald Trump is the single most unqualified human being to ever assume the presidency of the United States. He is mentally unfit. Not only does he not understand how government works, he has no interest in trying to find out how it works.” Reiner had been asked to compare Trump with President Lyndon B. Johnson, who was the subject of the director’s biopic “LBJ.”

“Make no mistake; we have a year before this country becomes a full-on autocracy, and democracy completely leaves us,” Reiner told MSNBC (since renamed MS NOW) in October. “And we’re looking at the election in 2026, and Donald Trump knows that in a free and fair election, he will lose. He will lose the House, the House will flip and will become in Democratic hands. There will be committee chairs who will be able to hold meetings, and this is the last thing he wants.”