Demi Moore won the award for best performance by an actress in a motion picture, The Substance.

Moore was nominated alongside Amy Adams (Nightbitch), Cynthia Erivo (Wicked), Karla Sofía Gascón (Emilia Pérez), Mikey Madison (Anora) and Zendaya (The Challengers).

The Globe marked Moore’s third nomination and first win.

“I really wasn’t expecting that. I’m just in shock right now! I’ve been doing this a long, like over 45 years and this is the first time I’ve ever won anything as an actor. And I’m just so humbled and so grateful,” she said when taking the stage.

The actress got to a point where she felt maybe she had already done what she was “supposed to do” and was at “low point” in her career when the “courageous” and “bonkers script” of The Substance came to her.

“I had a woman say to me, ‘Just know you will never be enough but you can know the value of your worth if you just put down your measuring stick,’” she said. She thanked the role for reminding her that she does “belong.”

Moore stars as Elisabeth Sparkle, an aging Hollywood star who embraces a secret cloning procedure to save her career. Coralie Fargeat directed the campy body horror film which also stars Margaret Qualley.

Discussing what drew her to the film, Moore said, “The script was such an interesting, out-of-the-box read, the way in which it was exploring the issue of aging. The thing that grabbed me was the exploration of the violence we can have against ourselves, that way in which we can dissect and criticize. I have found, at least in my own experience in life, that it’s really not what anyone else has ever done to me. The impact has always been on what I do to myself, internalized.”

“Everything was the kind of odd, intimate moments we have with ourselves, where we are often naked, looking, dissecting, thinking. It was really interesting challenge to create full life for her, because I didn’t have someone else to feed off of. It was also very technical.”