“When someone yells ‘Focker!’ on the street, it doesn’t necessarily feel respectful,” Stiller said with a laugh. “Whenever I’m treated by a male nurse,” he added, “I feel a connection.”

Roach reminded Stiller that he was almost never in the movie.

Spielberg was in talks to direct the film with Jim Carrey as the lead role. When the duo chose to depart the project, Roach was hired as the filmmaker and Stiller as the star.

“Jim Carrey was going to be me?” Stiller said. “Shit. I totally forgot that part.”

Polo joined the cast as the better half of Stiller’s fiancée-to-be at the last minute. “It was really late in the casting process, a few days before we started shooting,” Roach recalled. “She was thrown into it with these heavyweights.”

Polo joked that she spent the entire shoot “just sitting there, listening and reacting” to the ensemble around her. She remembers De Niro telling her that he doesn’t approach comedy any differently than he would a drama.

“He said, ‘It’s the same thing, It’s the honestly in which you say the line. You’re not trying to be funny. You say it and really mean it,’” Polo said.

Franchise: 2 Sequels

Meet the Parents was a commercial hit, grossing more than $330 million worldwide against a $55 million budget.

The foursome returned for 2004’s sequel “Meet the Fockers,” which introduced Greg’s parents (Barbra Streisand and Dustin Hoffman) who memorably taught audiences of the family’s bathroom policy: “If it’s yellow, let it mellow; if it’s brown, flush it down.”

A third movie, 2010’s “Little Fockers,” was critically panned but still earned $310 million at the box office.

Now, the “Meet the Parents” universe is expanding again. A fourth movie is in development with Ariana Grande among the new cast members. Stiller teased the fourquel, saying they needed an “organic reason” to revisit these characters.

“What spurred the idea is that I’m the age that Bob was when we did the first movie,” Stiller said. “It felt like a mirror to the first film, where one of my kids is thinking about introducing his person to the family.”

Though they didn’t share any plot details, De Niro revealed he’s read the screenplay. “The script is really fun.  I’m looking forward to it.”

De Niro claims he’s been pushing for another sequel for years now. “When we filmed the last one,” he said, “I was sitting with Ben and screenwriter John Hamburg. I said, ‘Let’s start writing the next one now.’ And they were just humoring me. Now we are finally doing the next one.”