Based on Friday earnings of $21.5 million, the Marvel Studios and Disney superhero tentpole is headed for domestic opening of less than $50 million to rank as the worst start in the history of the Marvel Cinematic Universe.

The Marvels marks a new low for Kevin Feige’s Marvel Studios, which for years was unrivaled in its success.

It promotes the theory that superhero fatigue is real as fanboys grow weary of titles and are far less forgiving.

Until now, rival DC was the superhero studio that endured the biggest ups and downs, with films opening to $50 million or less (in comparison, many MCU releases started off with $100 million or more domestically).

This summer, DC’s The Flash debuted to a dismal $55 million domestically on its way to topping out at paltry $270.6 million globally.

Word of mouth is already hurting The Marvels, which is only the third MCU title to receive a B CinemaScore from audiences after The Eternals and Ant-Man and the Wasp: Quantamania.

The vast majority of MCU releases have earned some variation of an A.

Its Rotten Tomatoes critics’ score of 62 percent is on the lower end. (Our grade was C).

The 33rd installment in the MCU is a sequel to the 2019 Brie Larson Mr Captain Marvel, which opened to $153.4 million in America on its way to earning massive $1.13 billion worldwide.

That movie was teased in the post-credit scene of 2018’s Avengers: Infinity War, while its titular star was player in 2019’s Avengers: Endgame

To date, 2008’s The Incredible Hulk holds the record for the lowest domestic opening of any MCU title at $55.4 million.

Marvel, which wasn’t owned by Disney at the time, partnered with Universal for Hulk.

The next lowest MCU opening belongs to Marvel/Disney’s Ant-Man, which started off with $57.2 million domestically in 2015.

In the new movie, Larson is joined by Iman Vellani, the breakout star of the Disney+ series Ms. Marvel, as well as Teyonah Parris as the grown-up version of Captain Marvel character Monica Rambeau. The actor made her Marvel debut with WandaVision, which counted The Marvels screenwriter Megan McDonnell among its writers.

The cast of The Marvels wasn’t able to do any promotion or publicity because of the SAG-AFTRA strike.

Overseas, The Marvels is pacing to open to $60 million for a global start of $140 million, compared to nearly $190 million for Captain Marvel.