El Sicario is mostly set in an anonymous motel room on the U.S.-Mexico border, where a Ciudad Juárez hit man speaks openly his mind.
He has killed hundreds of people and is an expert in torture and kidnapping. He was simultaneously on the payroll of the Mexican drug cartels and a commander of the Chihuahua State Police. There is currently a $250,000 contract on his life and he lives as a fugitive, though he has never been charged with a crime in any country.
With his face obscured by a black hood, he tells his story to the camera inside the very motel room he once used to hold and torture kidnapped victims. Aided only by a magic marker and note pad, which he uses to illustrate and diagram his words, the sicario describes, in astoundingly grphic detail, his life of crime, murder, abduction and torture.